General Assessment of SARS-CoV-2 patientS (GASS) score

Age < 45 (+0 points) 45-60 (+1 points) 61-75 (+2 points) 75-90 (+3 points) > 90 (+4 points)

Male? No (+0 points) Yes (+1 points)

Respiratory Rate (apm) <20 (+0 points) 20-30 (+1 points) >30 (+2 points)

paO2/FiO2 ratio >300 (+0 points) 200-300 (+1 points) 100-199 (+2 points) <100 (+3 points)

Lymphocytes count (n/mmc) >1000 (+0 points) 500-999 (+1 points) <500 (+2 points)

D-dimer (mcg/ml) <0.5 (+0 points) 0.5-2.0 (+1 points) >2.0 (+2 points)

Chronic Kidney Injury (moderate or severe) No (+0 points) Yes (+1 points)

estimated Glomerular Filtration (ml/min) >60 (+0 points) 45-60 (+1 points) 30-44 (+2 points) <30 (+3 points)

Troponin (ng/ml) <20 (+0 points) 20-50 (+1 points) >50 (+2 points)

Brain Natriuretic Peptide (pg/ml) <100 (+0 points) >100 (+1 points)

C Reactive Protein (mg/dl) 0-4.9 (+0 points) 5.0-10.0 (+1 points) >10.0 (+2 points)

Click here to fill the online GASS Score questionnaire

For info contact Dr N. Fabbri n.fabbri@ausl.fe.it, Dr S. Greco grcsvt@unife.it, Prof. A. Passaro psn@unife.it.

The retrospective analyses on 499 patients hospitalized for COVID-19, the GASS score was associated with both in-hospital death and 30-day death (p<0.001). Dividing the population into 3 categories, according to the GASS score, the association with the COVID-19 outcomes remained (p<0.001 for both variables). The Area Under Curve (AUC) generated by the GASS score towards 30-day death was 0.84, predicting this outcome more accurately than the Charlson Comorbidity Index (CCI, 0.74) and similarly to a LASSO-generated predictive model fitted on 151 variables considered (AUC=0.83).

Bibliography:

Greco, A. Salatiello, N. Fabbri, A. Passaro. "Early Prediction of COVID-19 Outcome: Contrasting Clinical Scores and Computational Intelligence Methods". Book title "Understanding Covid-19: The Role of Computational Intelligence" (Book Chapter).